Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure


Iron deficiency (ID) is associated with adverse outcomes in heart failure (HF) but the underlying mechanisms are incompletely understood ...


Reduced iron content, IRE binding activity, and transferrin receptor expression in the failing human heart

from math import ceil
import pandas as pd
from orkg import ORKG
from scipy.stats import ttest_ind

orkg = ORKG(host='')
orkg.templates.materialize_templates(['R12002', 'R12006', 'R12008'])
tp = orkg.templates

df = pd.read_csv('data.csv') 
tt = ttest_ind(df['non-failing heart (NF)'], 
               df['failing heart (F)'], 
               equal_var=False, nan_policy='omit')
pvalue = tt.pvalue
pvalue_ceil = ceil(pvalue * 1000) / 1000.0

  'Statistically significant hypothesis test with IRE binding dependent variable on failing and non-failing hearts (p<{})'.format(pvalue_ceil),
  '', # the study design dependent variable
  tp.pvalue('the p-value of the statistical hypothesis test (p<{})'.format(pvalue_ceil), tp.scalar_value_specification(pvalue)),
  'data.csv', # the input dataset
).serialize_to_file('article.contribution.1.json', as_jsonld=True)
Installing dependencies: 100%|████████████████████| 3/3 [00:01<00:00,  1.78it/s]

Consistent with previous reports 1Maeder et al.20112Leszek et al.2011 iron concentration was significantly lower in LV tissue samples from patients with advanced heart failure than in LV tissue samples from unused donor hearts. As shown by electrophoretic mobility shift assays, IRE binding activity was significantly (p<0.001) reduced in failing hearts (most pronounced in patients with ischemic cardiomyopathy) (Figure 1). Protein expression levels of the transferrin receptor were significantly lower in failing hearts than in the controls.

IRE binding activity for non-failing (NF) and failing (F) hearts.


    58Journal of the American College of Cardiology480474
    159International Journal of Cardiology5247